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Antiviral API
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Robinetin
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| Category | HIV Integrase |
| CAS | 490-31-3 |
| Description | Robinetin is from the leaves of Robinia pseudacacia. It inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. It could lead to the occurrence of positive induced circular dichroism (ICD) bands in the near ultra-violet (UV) region. |
Product Information
| Synonyms | 3,3',4',5',7-Pentahydroxy-flavon; 3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-one; Norkanugin; 5-Hydroxyfisetin |
| IUPAC Name | 3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one |
| Molecular Weight | 302.24 |
| Molecular Formula | C15H10O7 |
| Canonical SMILES | C1=CC2=C(C=C1O)OC(=C(C2=O)O)C3=CC(=C(C(=C3)O)O)O |
| InChI | InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H |
| InChIKey | SOEDEYVDCDYMMH-UHFFFAOYSA-N |
| Boiling Point | 669.9±55.0 °C at 760 mmHg |
| Melting Point | 326-328ºC |
| Flash Point | 258.6±25.0 °C |
| Purity | >98% |
| Density | 1.8±0.1 g/cm3 |
| Solubility | DMSO60 mg/mL (198.51 mM)60 mg/mL (198.51 mM) Ethanol3 mg/mL (9.92 mM)3 mg/mL (9.92 mM) WaterInsolubleInsoluble |
| Appearance | Yellow powder |
| Application | antioxidant/antiradical/anti-mutagenesis/anti-promotion |
| Storage | Powder: 3 years -20°C In solvent: 2 years -80°C |
| Complexity | 476 |
| Exact Mass | 302.04265265 |
| Index Of Refraction | 1.823 |
| In Vitro | Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner. Robinetin inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus. Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency. Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in 'two color' (in 'blue-violet' and 'yellow-green' regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore. |
| PSA | 131.36000 |
| Target | HIV Integrase |
| Vapor Pressure | 0.0±2.2 mmHg at 25°C |
| XLogP3-AA | 1.6 |
