RO8191

Category	Hepatitis C Virus (HCV)
CAS	691868-88-9
Description	RO8191 is an agonist of interferon α receptor type 2 (IFNAR2) effective against HCV with EC50 value of 200 nM. RO8191 phosphorylates STAT1 and STAT2, which functions as a gateway to the type I IFN signal cascade, and stimulates the phosphorylation of STAT3, 5 and 6.

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Synonyms	Ro 494-8191; 2-[2,4-bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole; 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine
Molecular Weight	373.2
Molecular Formula	C14H5F6N5O
Canonical SMILES	C1=CC2=NC(=CN2C3=C1C(=CC(=N3)C(F)(F)F)C(F)(F)F)C4=NN=CO4
InChI	InChI=1S/C14H5F6N5O/c15-13(16,17)7-3-9(14(18,19)20)23-11-6(7)1-2-10-22-8(4-25(10)11)12-24-21-5-26-12/h1-5H
InChIKey	GRHYZVJEXKTJOS-UHFFFAOYSA-N
Purity	≥98%
Solubility	In vitro: 10 mM in DMSO
Appearance	Crystalline Solid
Storage	-20°C, stored under nitrogen * In solvent : -80°C 6 months -20°C 1 month (stored under nitrogen)
Complexity	531
Exact Mass	373.03982877
In Vitro	RO8191 (RO4948191) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice. RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells. RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B.
In Vivo	RO8191 (RO4948191; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.
Target	IFNAR; JAK; STAT; HCV; HBV
XLogP3-AA	3.7