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RO6889678

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Category Hepatitis B Virus (HBV)
CAS 1578153-27-1
Description RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes.
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Product Information

Synonyms RO6889678|1578153-27-1|CHEMBL4064672|SCHEMBL15508072|SCHEMBL17874012|EX-A6634|BDBM50237769|AC-36756|HY-124364|CS-0086301|(3S)-4-[[(4R)-4-(2-chloro-4-fluorophenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid|(S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid
Molecular Weight 494.922
Molecular Formula C21H20ClFN4O5S
Canonical SMILES COC(=O)C1=C(NC(=NC1C2=C(C=C(C=C2)F)Cl)C3=NC=CS3)CN4CCOCC4C(=O)O
Purity ≥98% (HPLC)
Solubility Soluble in DMSO
Appearance Solid powder
Storage Store at -20°C
Complexity 831
Exact Mass 494.0826968
Target HBV; Cytochrome P450
XLogP3-AA -0.5

Description of First Aid Measures

Eye contact

Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.

Skin contact

Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.

Inhalation

Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.

Ingestion

Wash out mouth with water; Do NOT induce vomiting; call a physician.

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