RO-7

Category	Influenza Virus
CAS	1370241-45-4
Description	RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

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Synonyms	RO-7\|1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione\|CHEMBL4103104\|SCHEMBL10290465\|BDBM346802\|GLXC-15013\|US10202379, Reference Example 413\|HY-112684\|CS-0062623\|1-(5,11-Dihydro-10-thia-dibenzo[a,d]cyclohepten-5(S)-yl)-5-hydroxy-3-(2,2,2-trifluoro-1(R)-methyl-ethyl)-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione\|1370241-45-4\|R07
Molecular Weight	487.49
Molecular Formula	C24H20F3N3O3S
Canonical SMILES	CC(C(F)(F)F)N1CN(N2C=CC(=O)C(=C2C1=O)O)C3C4=CC=CC=C4CSC5=CC=CC=C35
Purity	≥98% (HPLC)
Solubility	In Vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	908
Exact Mass	487.11774717
In Vitro	RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses.
In Vivo	RO-7 protects mice from lethal challenge with both influenza A and B viruses.
Target	Influenza Virus
XLogP3-AA	5.3