RK-33

Category	SARS-CoV
CAS	1070773-09-9
Description	RK-33 is a first-in-class inhibitor of DDX3. It causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells, which has therapeutic use in cancers.

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Synonyms	RK-33;1070773-09-9;3,7-Dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one;RK33;RK 33;3,7-Bis(4-methoxybenzyl)-3,7-dihydro-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one;5,11-Bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one;COUMZXFUZDBRCZ-UHFFFAOYSA-N;3,7-Dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one;;SCHEMBL1313539;CHEMBL1672984;GLXC-10845;EX-A4211;VSB77309;RK-33?;s8246;AKOS032945047;CCG-268980;CS-5880;AC-33039;BS-14382;CID 46184988;DA-57464;HY-100455;D84049;5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexaazatricyclo[8.3.0.0(2),?]trideca-1(10),2,6,8,12-pentaen-4-one;
IUPAC Name	5,11-bis[(4-methoxyphenyl)methyl]-3,5,7,9,11,13-hexazatricyclo[8.3.0.02,6]trideca-1(10),2,6,8,12-pentaen-4-one
Molecular Weight	428.44
Molecular Formula	C23H20N6O3
Canonical SMILES	O=C1N(CC2=CC=C(OC)C=C2)C3=NC=NC4=C(N=CN4CC5=CC=C(OC)C=C5)C3=N1
InChI	InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
InChIKey	COUMZXFUZDBRCZ-UHFFFAOYSA-N
Appearance	Solid