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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Rilpivirine Hydrochloride
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| Category | SARS-CoV |
| CAS | 700361-47-3 |
| Description | Rilpivirine, also known as TMC278, is a drug used as a part of antiretroviral therapy (ART). Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs. |
Product Information
| Synonyms | Rilpivirine hydrochloride;Rilpivirine HCl;700361-47-3;TMC278 hydrochloride;Edurant;Endurant;UNII-212WAX8KDD;212WAX8KDD;Rilpivirine (as hydrochloride);CHEBI:68602;Rilpivirine hydrochloride [USAN];rilpivirine monohydrochloride;TMC-278 HYDROCHLORIDE;(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile hydrochloride;700361-47-3 (HCl);DTXSID80220320;Benzonitrile, 4-((4-((4-((1e)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)-, hydrochloride (1:1);JULUCA COMPONENT RILPIVIRINE HYDROCHLORIDE;ODEFSEY COMPONENT RILPIVIRINE HYDROCHLORIDE;EVIPLERA COMPONENT RILPIVIRINE HYDROCHLORIDE;TMC-278;Rilpivirine (hydrochloride);HCl, Rilpivirine;4-((4-((4-((E)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile hydrochloride;4-((4-((4-((E)-2-cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile hydrochloride;4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile hydrochloride;4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile hydrochloride;Edurant (TN);EDURANT PED;Hydrochloride, Rilpivirine;SCHEMBL1831067;TMC-278-LA;CHEMBL1628504;TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride;DTXCID80142811;KZVVGZKAVZUACK-BJILWQEISA-N;BCP13350;Rilpivirine hydrochloride (JAN/USAN);RILPIVIRINE HYDROCHLORIDE [MI];AKOS025149454;RILPIVIRINE HYDROCHLORIDE [JAN];4-((4-((4-((1E)-2-Cyanoethenyl)-2,6-dimethylphenyl)amino)pyrimidin-2- yl)amino)benzonitrile;RILPIVIRINE HYDROCHLORIDE [VANDF];AC-30620;DA-57448;RILPIVIRINE HYDROCHLORIDE [WHO-DD];D09958;RILPIVIRINE HYDROCHLORIDE [ORANGE BOOK];RILPIVIRINE HYDROCHLORIDE COMPONENT OF JULUCA;Q27137040;RILPIVIRINE HYDROCHLORIDE COMPONENT OF EVIPLERA;RILPIVIRINE HYDROCHLORIDE COMPONENT OF ODEFSEY;4-((4-((4-((1E)-2-Cyanoethenyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile monohydrochloride;4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile;hydrochloride;Benzonitrile, 4-((4-((4-((1E)-2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2- pyrimidinyl)amino)-, hydrochloride (1:1); |
| IUPAC Name | 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile;hydrochloride |
| Molecular Weight | 468.4 |
| Molecular Formula | C21H27Cl2N5O3 |
| Canonical SMILES | C1CC1N2C3=C(C=NC=C3)N(C2=O)CC4=NC5=CC=CC=C5N4CCCCO.O.Cl.Cl |
| InChI | InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);1H/b4-3+; |
| InChIKey | KZVVGZKAVZUACK-BJILWQEISA-N |
| Appearance | Solid |
| Application | Anti-HIV Agents |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |