Rifampicin-d4

Category	Influenza Virus
Description	Rifampicin-d4 (Rifampin-d4) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

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Synonyms	Rifampin-d4; Rifamycin AMP-d4
Molecular Weight	826.96
Molecular Formula	C43H54D4N4O12
Canonical SMILES	OC(C(/C=N/N1C([2H])([2H])CN(C)CC1([2H])[2H])=C(NC(/C(C)=C\C=C\[C@@H]([C@@H]([C@@H](C)[C@H]2O)O)C)=O)C(O)=C3C(O)=C4C)=C3C5=C4O[C@](C)(O/C=C/[C@@H]([C@H]([C@@]([C@@H]2C)([H])OC(C)=O)C)OC)C5=O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid
Storage	Store at -20°C
Complexity	1620
Exact Mass	826.43023028
In Vitro	Rifampicin (100 mg/mL) can block the functional activity of P-glycoprotein. Rifampicin is not a substract for P-glycoprotein. The mechanism of rifampicin resistance is unassociated with the functional activity of P-glycoprotein.
In Vivo	ifampicin (200, 400 mg/kg) can induce fatty liver at high concentration. Rifampicin (30 mg/kg, i.p.) treatment of S464P biofilms in vivo results in a slight decline, but earlier rebinds in bioluminescence from these catheters compared with the parental signal, whereas rifampicin has no affect on bioluminescence in mice infected with mutant H481Y.
Target	Bacterial; Influenza Virus; Antibiotic
XLogP3-AA	4.9