RdRP-IN-2

Category	SARS-CoV
CAS	2863657-16-1
Description	RdRP-IN-2 is a small molecule inhibitor designed to target RNA-dependent RNA polymerase (RdRP), an enzyme essential for the replication of RNA viruses. RdRP-IN-2 inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM. By inhibiting RdRP, RdRP-IN-2 aims to disrupt the viral replication process, potentially reducing the viral load and mitigating the severity of infections caused by RNA viruses. This type of inhibitor is valuable in the development of antiviral therapies, especially for diseases caused by viruses with RNA genomes, such as certain coronaviruses, flaviviruses, and other RNA viruses.

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Synonyms	(8-(Cyclohexyloxy)-1-oxo-2-phenyl-1H-benzo[4,5]thiazolo[3,2-a]pyridine-4-carbonyl)-L-phenylalanine; L-Phenylalanine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-; N-{[8-(Cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazol-4-yl]carbonyl}-L-phenylalanine
IUPAC Name	(2S)-2-[(8-cyclohexyloxy-1-oxo-2-phenylpyrido[2,1-b][1,3]benzothiazole-4-carbonyl)amino]-3-phenylpropanoic acid
Molecular Weight	566.67
Molecular Formula	C33H30N2O5S
Canonical SMILES	C1CCC(CC1)OC2=CC3=C(C=C2)SC4=C(C=C(C(=O)N34)C5=CC=CC=C5)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O
InChI	InChI=1S/C33H30N2O5S/c36-30(34-27(33(38)39)18-21-10-4-1-5-11-21)26-20-25(22-12-6-2-7-13-22)31(37)35-28-19-24(16-17-29(28)41-32(26)35)40-23-14-8-3-9-15-23/h1-2,4-7,10-13,16-17,19-20,23,27H,3,8-9,14-15,18H2,(H,34,36)(H,38,39)/t27-/m0/s1
InChIKey	BQZJTBOLNKPLGS-MHZLTWQESA-N
Boiling Point	798.9±60.0 °C at 760 mmHg
Purity	≥95%
Density	1.40±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Light yellow to yellow-green solid
Storage	Store at 2-8 °C