R803

Category	Hepatitis C Virus (HCV)
CAS	67700-30-5
Description	R803 is a potent and highly specific HCV replication inhibitor with EC50s of about 30 nM for genotype 1a and 1b replicons, and an EC50 of about 1,000 nM for genotype 2a replicon.

Quotation Now

Product Information

Synonyms	Furaprofen; Enprofen; 7-Benzofuranacetic acid, α-methyl-3-phenyl-; (±)-a-Methyl-3-phenyl-7-benzofuranacetic acid
IUPAC Name	2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
Molecular Weight	266.29
Molecular Formula	C17H14O3
Canonical SMILES	CC(C1=CC=CC2=C1OC=C2C3=CC=CC=C3)C(=O)O
InChI	InChI=1S/C17H14O3/c1-11(17(18)19)13-8-5-9-14-15(10-20-16(13)14)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
InChIKey	ODZUWQAFWMLWCF-UHFFFAOYSA-N
Boiling Point	449.4±33.0°C (Predicted)
Flash Point	225.6°C
Purity	≥95%
Density	1.230±0.06 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid Powder
Storage	Store at -20°C
Complexity	348
Exact Mass	266.094294304
Index Of Refraction	1.627
In Vitro	Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC50) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.
PSA	50.44000
Target	EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)
XLogP3-AA	4