QL47

Category	Dengue virus
CAS	1469988-75-7
Description	QL47 is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.

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Synonyms	QL47;1469988-75-7;9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone;CHEMBL4077064;QL-47;9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one;HMSL10077;QL-XII-47;SCHEMBL15334746;CHEBI:94815;DTXSID201025879;HMS3265M21;BCP30763;BDBM50245587;AKOS027323841;NCGC00346962-01;NCGC00346962-02;NCGC00346962-03;DA-67056;HY-80003;MS-28101;QL 47; QL-47; QL-XII-47;F85002;A909144;BRD-K99252563-001-01-1;Q27166580;Z2505483026;1-(1-Acryloylindolin-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one;9-(1-methylpyrazol-4-yl)-1-[1-(prop-2-enoyl)-2,3-dihydroindol-6-yl]benzo[h]1,6-naphthyridin-2-one;
IUPAC Name	9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one
Molecular Weight	447.49
Molecular Formula	C27H21N5O2
Canonical SMILES	O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CN(C)N=C4)C=C32)C5=CC=C(CC6)C(N6C(C=C)=O)=C5
InChI	InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3
InChIKey	RTRNJQOBEOISFQ-UHFFFAOYSA-N
Purity	0.98
Appearance	white solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.