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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
pUL89-Endonuclease-IN-2
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| Category | Cytomegalovirus (CMV) |
| CAS | 519021-48-8 |
| Description | pUL89 Endonuclease-IN-2 (Compound 15k) is a potent inhibitor of human cytomegalovirus (HCMV) pUL89 endonuclease with the IC50 of 3.0 μM. |
Product Information
| Synonyms | pUL89 Endonuclease-IN-2|SCHEMBL5122757|HY-146271|CS-0460459|5-hydroxy-6-oxo-2-thiophen-2-yl-N-[[4-(trifluoromethyl)phenyl]methyl]-1H-pyrimidine-4-carboxamide |
| Molecular Weight | 395.36 |
| Molecular Formula | C17H12F3N3O3S |
| Canonical SMILES | C1=CSC(=C1)C2=NC(=C(C(=O)N2)O)C(=O)NCC3=CC=C(C=C3)C(F)(F)F |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 670 |
| Exact Mass | 395.05514691 |
| In Vitro | pUL89-Endonuclease-IN-2 inhibited HCMV replication in HFF cell with the EC50 value of 14.4 μM. |
| Target | CMV |
| XLogP3-AA | 3.2 |
