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Pseudolaric acid B
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| Category | Hepatitis B Virus (HBV) |
| CAS | 82508-31-4 |
| Description | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. |
Product Information
| Synonyms | PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid |
| IUPAC Name | (2E,4E)-5-[(1S,7S,8S,9R)-7-acetyloxy-4-methoxycarbonyl-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid |
| Molecular Weight | 432.46 |
| Molecular Formula | C23H28O8 |
| Canonical SMILES | CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)O |
| InChI | InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22-,23-/m0/s1 |
| InChIKey | VDGOFNMYZYBUDT-YCONPBHISA-N |
| Boiling Point | 613.8±55.0 °C at 760 mmHg |
| Melting Point | 166°C |
| Flash Point | 208.8±25.0 °C |
| Purity | >98% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White cryst. |
| Application | Antifungal/antifertility |
| Storage | 4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light) |
| Complexity | 913 |
| Exact Mass | 432.17841785 |
| Index Of Refraction | 1.565 |
| PSA | 116.20000 |
| Target | HBV; Fungal; Apoptosis; Autophagy; Ferroptosis |
| Vapor Pressure | 0.0±3.8 mmHg at 25°C |
| XLogP3-AA | 2.3 |
