Pritelivir mesylate hydrate

Category	Herpes simplex Virus (HSV)
CAS	1428321-10-1
Description	Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex and has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with IC50s of both 0.02 μM against HSV1-2. It shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.

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Product Information

Synonyms	AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate; N-Methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-[4-(2-pyridinyl)phenyl]acetamide methanesulfonate hydrate (1:1:1); Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-, methanesulfonate, hydrate (1:1:1)
IUPAC Name	methanesulfonic acid;N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-(4-pyridin-2-ylphenyl)acetamide;hydrate
Molecular Weight	516.61
Molecular Formula	C19H24N4O7S3
Canonical SMILES	CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N.CS(=O)(=O)O.O
InChI	InChI=1S/C18H18N4O3S2.CH4O3S.H2O/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15;1-5(2,3)4;/h3-10H,11H2,1-2H3,(H2,19,24,25);1H3,(H,2,3,4);1H2
InChIKey	QPIDAZSAUYNBAC-UHFFFAOYSA-N
Purity	≥95%
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
In Vivo	Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex. Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS.
Target	HSV-1: 0.02 μM (IC50) HSV-2: 0.02 μM (IC50)