Pocapavir

Category	Enterovirus (EV)
CAS	146949-21-5
Description	Pocapavir has been found to be an antienterovirus agent that could probably be effctive against enterovirus infections. The Phase-II trial for Poliomyelitis has not been reported yet since 2012.

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Product Information

Synonyms	SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073; 1,3-Dichloro-2-({4-[(2-chloro-4-methoxyphenoxy)methyl]benzyl}oxy)benzene; 1[2-chloro-4-methoxy-phenyl-oxymethyl]-4-[2,6-dichloro-phenyl-oxymethyl]-benzene; Benzene,1-[(2-chloro-4-methoxyphenoxy)methyl]-4-[(2,6-dichlorophenoxy)methyl]
Molecular Weight	423.71
Molecular Formula	C21H17Cl3O3
Canonical SMILES	COC1=CC(=C(C=C1)OCC2=CC=C(C=C2)COC3=C(C=CC=C3Cl)Cl)Cl
InChI	InChI=1S/C21H17Cl3O3/c1-25-16-9-10-20(19(24)11-16)26-12-14-5-7-15(8-6-14)13-27-21-17(22)3-2-4-18(21)23/h2-11H,12-13H2,1H3
InChIKey	XXMDDBVNWRWNCW-UHFFFAOYSA-N
Boiling Point	541.4±45.0 °C at 760 mmHg
Flash Point	176.5±28.8 °C
Purity	98%
Density	1.3±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Powder
Storage	Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Complexity	421
Exact Mass	422.024327
Index Of Refraction	1.606
In Vitro	Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance. Pocapavir, an investigational oral antiviral, has been used in a case of neonatal enterovirus sepsis. Pocapavir, also known as SCH 48973 and V-073, is a potent, selective anti-enteroviral agent only available as an emergency investigational drug. Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication.
Target	Enterovirus
Vapor Pressure	0.0±1.4 mmHg at 25°C
XLogP3-AA	6.7