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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
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- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
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- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
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- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
PF 429242 dihydrochloride
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| Category | Virus Protease |
| CAS | 2248666-66-0 |
| Description | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. |
Product Information
| Synonyms | PF-429242 dihydrochloride; PF429242 dihydrochloride |
| IUPAC Name | 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide;dihydrochloride |
| Molecular Weight | 482.49 |
| Molecular Formula | C25H35N3O2·2HCl |
| Canonical SMILES | CCN(CC)CC1=CC=C(C=C1)C(=O)N(CCC2=CC=CC=C2OC)C3CCNC3.Cl.Cl |
| InChI | InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1 |
| InChIKey | GSUZWFZKTIOWTI-MQWQBNKOSA-N |
| Purity | ≥97% by HPLC |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White to light brown (Solid) |
| Storage | 4°C, sealed storage, away from moisture |
| Target | Fatty Acid Synthase (FASN); Virus Protease |
