-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
PF-429242
![{PARAM:[Name]}()](https://resource.bocsci.com/structure/947303-87-92d.gif)
| Category | Virus Protease |
| CAS | 947303-87-9 |
| Description | PF 429242 is a reversible, competitive, cell permeable inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM) without disrupting a panel of serine proteases. Some studies reported that the inhibition of SKI-1/S1P, a master lipo- 387 genic regulator, could impair HCV genome replication, lipid droplet 388 homeostasis and the production of infectious HCV virions. |
Product Information
| Synonyms | 947303-87-9;PF-429242;(R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide;PF 429242;49WB3OA7VN;CHEMBL233611;(-)-PF-429242;PF-429242 dihydrochloride;PF429242;Benzamide, 4-((diethylamino)methyl)-N-(2-(2-methoxyphenyl)ethyl)-N-(3R)-3-pyrrolidinyl-;UNII-49WB3OA7VN;4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide;SCHEMBL2742702;DTXSID00635376;EX-A1409;BDBM50216181;s6418;AKOS015998619;(R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benz amide;NCGC00387092-01;NCGC00387092-02;NCGC00387092-03;HY-13447;DB-362343;CS-0006904;PF 429242?;J-502224;Q27259314;(R)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl)-N-(pyrrolidin-3-yl)benzamide;4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide;4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide; |
| IUPAC Name | 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide |
| Molecular Weight | 409.56 |
| Molecular Formula | C25H35N3O2 |
| Canonical SMILES | O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3 |
| InChI | InChI=1S/C25H35N3O2/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3/h6-13,23,26H,4-5,14-19H2,1-3H3/t23-/m1/s1 |
| InChIKey | XKPJTOHUPQWSOJ-HSZRJFAPSA-N |
| Boiling Point | 562.2±50.0 °C | Condition: Press: 760 Torr |
| Density | 1.11±0.1 g/cm3 |
| Solubility | Soluble to 50 mM in water and to 50 mM in DMSO |
| Appearance | White solid |
| Shelf Life | 2 years |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
