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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Penciclovir sodium
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| Category | Herpes simplex Virus (HSV) |
| CAS | 97845-62-0 |
| Description | Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse |
Product Information
| Synonyms | Penciclovir sodium|UNII-P06226385L|P06226385L|Penciclovir sodium [USAN]|BRL-39123-D|Penciclovir cream|97845-62-0|BRL 39123-D|Q27285959|9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine monosodium salt|1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt|2-Amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt |
| IUPAC Name | sodium;4-(2-amino-6-oxo-1H-purin-9-yl)-2-(hydroxymethyl)butan-1-olate |
| Molecular Weight | 275.2426 |
| Molecular Formula | C10H14N5NaO3 |
| Canonical SMILES | C1=NC2=C(N1CCC(CO)CO)N=C([N-]C2=O)N.[Na+] |
| InChI | InChI=1S/C10H14N5O3.Na/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17;/h5-6,16H,1-4H2,(H3,11,13,14,18);/q-1;+1 |
| InChIKey | BRPTUOYNOCSFRJ-UHFFFAOYSA-N |
| Purity | 95% |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 350 |
| Exact Mass | 275.09943361 |
| In Vitro | Penciclovir sodium (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively. Penciclovir sodium (0-100 µg/ml) shows no-toxic to uninfected human cells. |
| In Vivo | Penciclovir sodium (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse. |
| PSA | 132.88000 |
| Target | HSV |
