PD 169316

Category	Enterovirus (EV)
CAS	152121-53-4
Description	PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.

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Product Information

Synonyms	PD-169316; PD 169316; PD169316.
Molecular Weight	360.348
Molecular Formula	C20H13FN4O2
Canonical SMILES	C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)[N+](=O)[O-]
InChI	InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
InChIKey	BGIYKDUASORTBB-UHFFFAOYSA-N
Boiling Point	583.1±50.0 °C at 760 mmHg
Flash Point	306.4±30.1 °C
Purity	98.0%
Density	1.4±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Light yellow to yellow (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	495
Exact Mass	360.10225383
Index Of Refraction	1.651
In Vitro	PD169316 (10 μM) inhibits TGFβ and Activin A, but not BMP4 signaling in CaOV3 cells. PD169316 (0.2-20 μM) inhibits TGFβ-induced Smad2 nuclear translocation, Smad7 mRNA induction, and reporter gene activity in CaOV3 cells. PD169316 (10 μM) shows a significantly increased rate of proliferation in Nestin knockdown cells, and can rescue the effect of Nestin knockdown on cell viability in the absence of EGF. PD169316 significantly inhibits p38 MAP kinase activity with no significant change in ERK activity in PC12 cells. PD169316 (10 μM) blocks Apoptosis induced by trophic factor withdrawal in differentiated PC12 cells.
In Vivo	PD169316 (30 ng/5 μL) or in combination with U0126 improves spatial learning in MWM in Aβ-injected rats, 20 days after Aβ-injection. Pretreatment with U0126 and PD169316 decreases the levels of phosphorylated form of ERK and p38 to about 77.7 and 64.2%, respectively, and causes a significant increase in c-fos, p-CREB, NRF-1 and TFAM protein levels, compared to the Aβ-injected group.
PSA	87.39000
Target	IC50: 89 nM (p38 MAPK)
Vapor Pressure	0.0±1.6 mmHg at 25°C
XLogP3-AA	3.9