Palmitoyl Ethanolamide-[7,7,8,8-d4]

Category	Influenza Virus
CAS	1159908-45-8
Description	Palmitoyl Ethanolamide-[7,7,8,8-d4] is the labelled analogue of Palmitoylethanolamide, which is an endogenous CB2 cannabinoid receptor agonist and a selective GPR55 agonist.

Quotation Now

Product Information

Synonyms	Palmitoyl Ethanolamide D4; N-(Hexadecanoyl)-ethanolamine(d4); Palmitoyl-EA(d4)
IUPAC Name	7,7,8,8-tetradeuterio-N-(2-hydroxyethyl)hexadecanamide
Molecular Weight	303.52
Molecular Formula	C18H33D4NO2
Canonical SMILES	CCCCCCCCCCCCCCCC(=O)NCCO
InChI	InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)/i9D2,10D2
InChIKey	HXYVTAGFYLMHSO-YQUBHJMPSA-N
Boiling Point	461.5±28.0 °C at 760 mmHg
Flash Point	232.9±24.0 °C
Purity	95% atom D
Density	0.9±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	219
Exact Mass	303.307536407
Index Of Refraction	1.463
In Vitro	Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of Palmitoylethanolamide, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. Palmitoylethanolamide is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which Palmitoylethanolamide decreased the toxicity of virus in the organism is discussed.
PSA	49.33000
Target	Influenza Virus; Endogenous Metabolite
Vapor Pressure	0.0±2.6 mmHg at 25°C
XLogP3-AA	6.2