Palmatine hydrochloride

Category	Virus Protease
CAS	10605-02-4
Description	Palmatine hydrochloride (Palmatine chloride) is a hydrochloride salt of palmatine, a protoberberine alkaloid that has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. It acts as an inhibitor of dopamine generation which reduces Ca2+ levels.

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Product Information

Synonyms	Palmatine chloride; 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride
IUPAC Name	2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
Molecular Weight	387.86
Molecular Formula	C21H22ClNO4
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
InChI	InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
InChIKey	RLQYRXCUPVKSAW-UHFFFAOYSA-M
Melting Point	205 °C
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	White Solid
Storage	4°C, sealed storage, away from moisture and light * In solvent : -80°C 6 months; -20°C 1 month (sealed storage, away from moisture and light)
Complexity	475
Exact Mass	352.15488318
Index Of Refraction	1.624
In Vitro	Palmatine (0-100 μM; 42 h) suppresses WNV with an EC50 value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC50 values of 26.4 μM and 7.3 μM, respectively. Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation. Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces Apoptosis in colon cancer cells via the mitochondrial associated pathway.
In Vivo	Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells. Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice. Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice. Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice.
PSA	40.80000
Target	Indoleamine 2,3-Dioxygenase (IDO); Virus Protease; Aurora kinase; Apoptosis;
Vapor Pressure	6.6E-15mmHg at 25°C
XLogP3-AA	3.7