| Synonyms |
Biosolvomycin; Engemycin; Oxamycen; Terramycin hydrochloride; Bisolvomycin; Dalimycin; Unimycin |
| IUPAC Name |
(4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride |
| Molecular Weight |
496.90 |
| Molecular Formula |
C22H24N2O9.HCl |
| Canonical SMILES |
CC1(C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O)O.Cl |
| InChI |
1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1 |
| InChIKey |
SVDOODSCHVSYEK-IFLJXUKPSA-N |
| Boiling Point |
839.6°C at 760 mmHg |
| Melting Point |
198-202°C |
| Flash Point |
461.6°C |
| Purity |
≥97% |
| Density |
1.71 g/cm3 |
| Solubility |
Soluble in Methanol, Ethanol, DMF, DMSO, Water |
| Appearance |
Yellow Crystalline Solid |
| Application |
Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial. |
| Storage |
Store at 2-8°C |
| Complexity |
1000 |
| Exact Mass |
496.1248581 |
| In Vitro |
Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes. |
| In Vivo |
The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days. |
| PSA |
201.85000 |
| Target |
Bacterial; HSV; Antibiotic; Endogenous Metabolite |
| Vapor Pressure |
2.17E-30mmHg at 25°C |
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