Oseltamivir EP Impurity C

Category	Influenza Virus
CAS	187227-45-8
Description	Oseltamivir EP Impurity C is the active metabolite of oseltamivir. Oseltamivir, also called as GS 4071 or Ro 64-0802, is an antiviral drug that competitively inhibits neuraminidase A and B (IC50 = 0.1 to 4.9 nM).

Quotation Now

Synonyms	Oseltamivir Acid (USP); Oseltamivir carboxylate; GS 4071; Ro 64-0802; Oseltamivir Carboxylic Acid
IUPAC Name	(3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylic acid
Molecular Weight	284.35
Molecular Formula	C14H24N2O4
Canonical SMILES	CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)O
InChI	1S/C14H24N2O4/c1-4-10(5-2)20-12-7-9(14(18)19)6-11(15)13(12)16-8(3)17/h7,10-13H,4-6,15H2,1-3H3,(H,16,17)(H,18,19)/t11-,12+,13+/m0/s1
InChIKey	NENPYTRHICXVCS-YNEHKIRRSA-N
Boiling Point	508.7±50.0 °C \| Condition: Press: 760 Torr
Melting Point	185-187 °C
Flash Point	261.5±30.1 °C
Purity	≥98%
Density	1.15 g/cm3
Solubility	Soluble to ≥ 56 mg/mL in H2O
Appearance	White Solid
Application	A metabolite of Oseltamivir.
Shelf Life	2 years
Storage	Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -64°C for long term (months to years).
Animal Admin	Compared with the untreated cohorts, Oseltamivir treatment (30 mg/kg, q.d., i.p.) reduced tumor vascularization and growth rate, as well as significantly reduced tumor weight and spread to the lungs. At the dosage of 50 mg/kg, Oseltamivir completely ablated tumor vascularization, tumor growth and spread to the lungs, with significant long-term survival at day 180 postimplantation, tumor shrinking, and no relapses after 56 days off-drug.
Complexity	391
Exact Mass	284.17360725
Index Of Refraction	1.525
PSA	101.65000
Target	Influenza A and B
Vapor Pressure	0.0±2.8 mmHg at 25°C
XLogP3-AA	-1.9