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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Omaciclovir
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| Category | Herpes simplex Virus (HSV) |
| CAS | 124265-89-0 |
| Description | This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral thymidine kinase to its monophosphate form and it is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase. Preclinical trials for Herpes simplex virus infections, HIV infections and Varicella zoster virus infections were discontinued. |
Product Information
| Synonyms | ABT-091; ABT091; ABT 091; H2G; H 2G; (-)-2HM-HBG; A-182091; 2HMHBG; Omaciclovir; 2-HMHBG; UNII-C9H909GLI3; Omaciclovir [USAN:INN]; C9H909GLI3; H 2G;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one |
| Molecular Weight | 253.26 |
| Molecular Formula | C10H15N5O3 |
| Canonical SMILES | C1=NC2=C(N1CC(CCO)CO)NC(=NC2=O)N |
| InChI | InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)/t6-/m1/s1 |
| InChIKey | SCBFBAWJWLXVHS-ZCFIWIBFSA-N |
| Boiling Point | 637.8°C at 760 mmHg |
| Flash Point | 339.5°C |
| Purity | 98% |
| Density | 1.68g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Powder |
| Application | Herpes simplex virus infections, HIV infections and Varicella zoster virus infections |
| Shelf Life | 2 month in rt, long time |
| Storage | -20°C Freezer |
| Complexity | 348 |
| Exact Mass | 253.11748936 |
| Index Of Refraction | 1.748 |
| In Vitro | Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys. Omaciclovir shows antiviral activities against different human herpesviruses with EC50s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively. |
| PSA | 131.04000 |
| Target | HSV |
| Vapor Pressure | 3.85E-17mmHg at 25°C |
| XLogP3-AA | -1.9 |
