Nucleozin

Category	Influenza Virus
CAS	341001-38-5
Description	Nucleozin is a cell-permeable isoxazolylpiperazine, which targets influenza a nucleoprotein (NP) to inhibit influenza A H1N1, H3N2 and H5N1.

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Synonyms	1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine; [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone
IUPAC Name	[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
Molecular Weight	426.85
Molecular Formula	C21H19ClN4O4
Canonical SMILES	CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N3CCN(CC3)C4=C(C=C(C=C4)[N+](=O)[O-])Cl
InChI	InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChIKey	OWXBJAPOSQSWAO-UHFFFAOYSA-N
Boiling Point	673.8°C at 760 mmHg
Flash Point	361.3°C
Purity	≥98%
Density	1.371 g/cm3
Solubility	Soluble in DMSO
Appearance	Yellow powder
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	Store at -20 °C
Complexity	619
Exact Mass	426.1094828
Index Of Refraction	1.631
In Vitro	Nucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an 50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA) , respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays.
PSA	95.40000
Target	Influenza Virus
XLogP3-AA	3.9