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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Norwogonin
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| Category | Enterovirus (EV) |
| CAS | 4443-09-8 |
| Description | Norwogonin is a flavonoid isolated from Scutellaria baicalensis Georgi, showing antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml. |
Product Information
| Synonyms | 5,7,8-Trihydroxyflavone; 5,7,8-Trihydroxy-2-phenyl-4H-chromen-4-one |
| Molecular Weight | 270.2 |
| Molecular Formula | C15H10O5 |
| Canonical SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O |
| InChI | InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H |
| InChIKey | ZFKKRRMUPBBYRS-UHFFFAOYSA-N |
| Boiling Point | 528.4ºC at 760 mmHg |
| Melting Point | 258 ºC (ethanol ) |
| Flash Point | 206ºC |
| Purity | 98% |
| Density | 1.548g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Powder |
| Storage | 4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light) |
| Complexity | 413 |
| Exact Mass | 270.05282342 |
| Index Of Refraction | 1.732 |
| In Vitro | Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection. Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression. Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h. |
| PSA | 90.90000 |
| Target | IC50: 31.83 μg/ml (EV71) |
| XLogP3-AA | 2.7 |
