Norwogonin

Category	Enterovirus (EV)
CAS	4443-09-8
Description	Norwogonin is a flavonoid isolated from Scutellaria baicalensis Georgi, showing antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml.

Quotation Now

Synonyms	5,7,8-Trihydroxyflavone; 5,7,8-Trihydroxy-2-phenyl-4H-chromen-4-one
Molecular Weight	270.2
Molecular Formula	C15H10O5
Canonical SMILES	C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
InChI	InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H
InChIKey	ZFKKRRMUPBBYRS-UHFFFAOYSA-N
Boiling Point	528.4°C at 760 mmHg
Melting Point	258 °C (ethanol )
Flash Point	206°C
Purity	98%
Density	1.548g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Powder
Storage	4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light)
Complexity	413
Exact Mass	270.05282342
Index Of Refraction	1.732
In Vitro	Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection. Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression. Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h.
PSA	90.90000
Target	IC50: 31.83 μg/ml (EV71)
XLogP3-AA	2.7