Nitazoxanide

Category	Influenza Virus
CAS	55981-09-4
Description	Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used in medicine for the treatment of various helminthic, protozoal, and viral infections. Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM)

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Product Information

Synonyms	2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide; N-(5-Nitro-2-thiazolyl)salicylamide Acetate Ester; Nizonide
IUPAC Name	[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
Molecular Weight	307.28
Molecular Formula	C12H9N3O5S
Canonical SMILES	CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChI	InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
InChIKey	YQNQNVDNTFHQSW-UHFFFAOYSA-N
Melting Point	198-200°C
Purity	>98%
Density	1.532 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Off-white to Pale Yellow Solid
Application	Antiparasitic Agents
Storage	Store at 2-8°C
Complexity	428
Exact Mass	307.02629157
Index Of Refraction	1.673
In Vitro	Giardia lamblia, a flagellated protozoan, is the most common causative agent of persistent diarrhea worldwide. Nitazoxanide exhibits effect on G. lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM. The number of parasites still attached to Caco2 cells after 24 h decreased to less than 20% of the control value in the presence of 30 μM Nitazoxanide with an inoculum density of 105 trophozoites.
In Vivo	Nitazoxanide exhibits a wide spectrum of in vivo activity against a broad spectrum of intestinal parasites, such as Giardia lamblia, Entamoeba histolytica, Trichomonas vaginalis, the apicomplexan Cryptosporidium parvum, and enteric bacteria infecting animals and humans. Nitazoxanide (50, 75 or 100 mg/kg/day; administered daily by intragastric for up to 25 days) reduces the mortality of Japanese encephalitis virus (JEV) strain-infected mice and protected mice from a lethal dose challenge of JEV[.
PSA	142.35000
Target	Parasite; Influenza Virus; Autophagy
XLogP3-AA	2