-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
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- Flavivirus
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- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
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- HIF/HIF Prolyl-Hydroxylase
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- HIV Protease
- Human immunodeficiency Virus (HIV)
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- Rabies virus (RABV)
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- Antiviral intermediates
Nevirapine-[d3]
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 1051419-24-9 |
| Description | Nevirapine-[d3] is the labelled analogue of Nevirapine. Nevirapine is an anti-HIV drug that reduces the amount of virus in the body. |
Product Information
| Synonyms | Nevirapine D3 |
| IUPAC Name | 2-cyclopropyl-7-(trideuteriomethyl)-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one |
| Molecular Weight | 269.32 |
| Molecular Formula | C15H11D3N4O |
| Canonical SMILES | CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4 |
| InChI | InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)/i1D3 |
| InChIKey | NQDJXKOVJZTUJA-FIBGUPNXSA-N |
| Melting Point | 234-236°C |
| Purity | 95% atom D |
| Solubility | Soluble in DMSO, Methanol |
| Appearance | White to Pale Beige Solid |
| Application | Labelled Nevirapine (N391275), a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral. |
| Storage | Store at -20°C |
| Complexity | 397 |
| Exact Mass | 269.13559132 |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs. |
| PSA | 61.61000 |
| Target | HIV; Reverse Transcriptase |
| XLogP3-AA | 2 |
Description of First Aid Measures
Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.
Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.
InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.
IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.