Neuraminidase-IN-11

Category	Influenza Virus
CAS	2685786-28-9
Description	Neuraminidase-IN-11 (15e) is a potent and selective neuraminidase (NA) inhibitor with the IC50 values of 4.7 nM, 8.46 nM and 1.5 nM against H1N1, H5N1 and H5N8 NAs respectively.

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Synonyms	Neuraminidase-IN-11\|HY-151104\|CS-0567594
Molecular Weight	486.62
Molecular Formula	C26H34N2O5S
Canonical SMILES	CCC(CC)OC1C=C(CC(C1NC(=O)C)NCC2=C(C=C(C=C2)C3=CSC=C3)OC)C(=O)O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	713
Exact Mass	486.21884336
In Vitro	Neuraminidase-IN-11 (15e) (0-6 μM, 40 min)has anti-NA (Neuraminidase) activity against H1N1-H274Y mutant and H5N1-H274Y mutant with the IC50 values of 1.07 μM and 0.61 μM, respectively. Neuraminidase-IN-11 (15e) (0-20 μM, 48 h) inhibits chicken embryo fibroblasts (CEFs) infected H5N1 or H5N8 with the IC50 values of 4.4 μM and 0.57 μM respectively, and inhibits Madin-Darby canine kidney (MDCK) cells infected H1N1 or H3N2 with the IC50 values of 0.05 μM and 12.65 μM respectively. Neuraminidase-IN-11 (15e) has no significant inhibitory effect on the major CYP enzymes which acts on CYP1A2, CYP2C9 and CYP2C19 with the IC50 values of 28.9 μM, 47.3 μM and 47.8 μM, respectively. The Metabolic stability parameters of Neuraminidase-IN-11 (15e) in human liver microsomes (HLM).
In Vivo	Neuraminidase-IN-11 (15e) (oral administration, 50 mg/kg, every second day, 14 days) shows no significant change in body weight and no other toxic side effects in kunming mice.
Target	Influenza Virus
XLogP3-AA	1.4