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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
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- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
Neuraminidase-IN-10
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| Category | Influenza Virus |
| CAS | 2685786-29-0 |
| Description | Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively. |
Product Information
| Synonyms | Neuraminidase-IN-10|HY-151103|CS-0567589 |
| Molecular Weight | 486.62 |
| Molecular Formula | C26H34N2O5S |
| Canonical SMILES | CCC(CC)OC1C=C(CC(C1NC(=O)C)NCC2=C(C=C(C=C2)C3=CC=CS3)OC)C(=O)O |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 713 |
| Exact Mass | 486.21884336 |
| In Vitro | Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC50 value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC50 values of 0.04 ± 0.04 and 28.70 ± 1.61 μM, respectively in MDCK Cells. |
| In Vivo | Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model. |
| Target | Influenza Virus |
| XLogP3-AA | 1.4 |
