Nafamostat hydrochloride

Category	SARS-CoV
CAS	80251-32-7
Description	Nafamostat hydrochloride is a synthetic serine protease inhibitor. It is used as an anticoagulant. It is similar to Tranilast.

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Product Information

Synonyms	Benzoic acid,4-[(aminoiminomethyl)amino]-,6- (aminoiminomethyl)-2-naphthalenyl ester,dihydrochloride;Nafamostat mesylate dihydrochloride;6-Amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate dihydrochloride
Molecular Weight	420.29
Molecular Formula	C19H19N5O2Cl2
Canonical SMILES	O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3.Cl.Cl
InChI	InChI=1S/C19H17N5O2.2ClH/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;;/h1-10H,(H3,20,21)(H4,22,23,24);2*1H
Melting Point	264-266 °C
Purity	>98%
Solubility	10 mM in DMSO
Appearance	Solid powder
Application	Nafamostat hydrochloride is used as an anticoagulant.
Shelf Life	2 month in rt, long time
Storage	-20°C Freezer
In Vitro	Tranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.
PSA	138.07000
Target	Ser/Thr Protease; Apoptosis; SARS-CoV