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Antiviral API
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- Antiviral intermediates
N6-Methyladenosine
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| Category | Influenza Virus |
| CAS | 1867-73-8 |
| Description | N6-Methyladenosine is an abundant modification in mRNA and is found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. |
Product Information
| Synonyms | 6-Methyladenosine; N(6)-Methyladenosine; N-Methyladenosine; 6-Methylaminopurinosine; 6-Methylaminopurine D-riboside; 6-Methylaminopurine ribonucleoside; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol; NSC 29409; 6-Methylamino-9-β-D-ribofuranosylpurine; 6-Methylaminopurine riboside; 9-β-D-Ribofuranosyl-N6-methylaminopurine; N6-methyladenosine (m6A) |
| IUPAC Name | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol |
| Molecular Weight | 281.27 |
| Molecular Formula | C11H15N5O4 |
| Canonical SMILES | CNC1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)O)O |
| InChI | InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | VQAYFKKCNSOZKM-IOSLPCCCSA-N |
| Boiling Point | 649.1±65.0°C (Predicted) |
| Melting Point | 172°C |
| Flash Point | 346.3°C |
| Purity | >98% |
| Density | 1.85±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO (10 mM) |
| Appearance | White Solid |
| Storage | Store at 2-8°C |
| Complexity | 349 |
| Exact Mass | 281.11240398 |
| Index Of Refraction | 1.814 |
| In Vitro | N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits. |
| PSA | 125.55000 |
| Target | Influenza Virus; Endogenous Metabolite |
| Vapor Pressure | 9.86E-18mmHg at 25°C |
| XLogP3-AA | -0.4 |
