N-Acetyl-L-cysteine

Category	Endogenous Metabolite
CAS	616-91-1
Description	N-Acetyl-L-cysteine is an antioxidant and precursor to glutathione. It has potential anticancer activity against tumor cell growth. Nutritional supplement in health care products.

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Product Information

Synonyms	Acetylcysteine; N-Acetylcysteine; Mercapturic acid; Acetadote; (2R)-2-acetamido-3-sulfanylpropanoic acid
IUPAC Name	(2R)-2-acetamido-3-sulfanylpropanoic acid
Molecular Weight	163.19
Molecular Formula	C5H9NO3S
Canonical SMILES	CC(=O)NC(CS)C(=O)O
InChI	InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
InChIKey	PWKSKIMOESPYIA-BYPYZUCNSA-N
Boiling Point	407.7°C at 760 mmHg
Melting Point	106-110 °C
Flash Point	200.4°C
Purity	95%
Density	1.294 g/cm3
Solubility	Soluble in DMSO, Methanol, Water
Appearance	White crystals or crystalline powder
Application	Ingredient of health care products.
Storage	Store at RT
Complexity	148
Exact Mass	163.030319
Index Of Refraction	1.519
In Vitro	Acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. Acetylcysteine also prevents death of PC12 cells and sympathetic neurons. Acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. Acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. Acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. Acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. Acetylcysteine interferes with redox-sensitive steps in the NGF mechanism.
In Vivo	Acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment.
PSA	105.20000
Target	Human Endogenous Metabolite
Vapor Pressure	0.0±2.0 mmHg at 25°C
XLogP3-AA	0.4