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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Mosloflavone
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| Category | Enterovirus (EV) |
| CAS | 740-33-0 |
| Description | Mosloflavone is a flavonoid with anti-EV71 and promising anti-inflammatory activity. |
Product Information
| Synonyms | 5-Hydroxy-6,7-dimethoxyflavone |
| Molecular Weight | 298.3 |
| Molecular Formula | C17H14O5 |
| Canonical SMILES | COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC |
| InChI | InChI=1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3 |
| InChIKey | SIVAITYPYQQYAP-UHFFFAOYSA-N |
| Boiling Point | 508.5±50.0 °C at 760 mmHg |
| Melting Point | 163-164°C (chloroform , acetone ) |
| Flash Point | 190.5±23.6 °C |
| Purity | 0.98 |
| Density | 1.3±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Powder |
| Storage | 4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light) |
| Complexity | 440 |
| Exact Mass | 298.08412354 |
| Index Of Refraction | 1.622 |
| In Vitro | Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. |
| PSA | 68.90000 |
| Target | IC50: EV71; bacterial |
| Vapor Pressure | 0.0±1.4 mmHg at 25°C |
| XLogP3-AA | 3.3 |
