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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
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- HCV Protease
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- Human immunodeficiency Virus (HIV)
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- Influenza Virus
- Orthopoxvirus
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- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
ML303
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| Category | Influenza Virus |
| CAS | 1638211-04-7 |
| Description | ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1. |
Product Information
| Synonyms | ML303|1638211-04-7|NCGC00248767-01|2-Methoxy-4-[3-methyl-1-[4-(trifluoromethyl)phenyl]pyrazolo[3,4-b]pyridin-4-yl]phenol|ml-303|MLS004256089|CHEMBL4438173|EX-A4992|AKOS037643532|ZINC215969162|DC60130|AS-16802|ML303, >=98% (HPLC)|SMR003080964|CID 136141525|HY-126136|CS-0090741 |
| Molecular Weight | 399.37 |
| Molecular Formula | C21H16F3N3O2 |
| Canonical SMILES | CC1=NN(C2=NC=CC(=C12)C3=CC(=C(C=C3)O)OC)C4=CC=C(C=C4)C(F)(F)F |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White to off-white (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 556 |
| Exact Mass | 399.11946125 |
| In Vitro | ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells. Western Blot Analysis Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours Concentration: 20 μM Incubation Time: 6 hours Result: Restored IFN-β mRNA levels in MDCK cells |
| In Vivo | ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells. |
| Target | Influenza Virus |
| XLogP3-AA | 5 |
