MI-1851

Category	SARS-CoV
CAS	2417283-44-2
Description	MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity.

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Synonyms	CHEMBL4790628\|MI-1851\|BDBM50552672\|HY-150737\|CS-0542649
Molecular Weight	767.88
Molecular Formula	C34H53N15O6
Canonical SMILES	CC(C)(C)C(C(=O)NC(CCON=C(N)N)C(=O)NCC1=CC=C(C=C1)C(=N)N)NC(=O)C(CCON=C(N)N)NC(=O)CC2=CC=C(C=C2)CN=C(N)N
Purity	≥98% (HPLC)
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Appearance	White to Pale Yellow Solid
Storage	Store at -20°C
Complexity	1360
Exact Mass	767.43032447
In Vitro	MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner. MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold. MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells.
Target	SARS-CoV
XLogP3-AA	-1.6