Methylprednisolone-d3

Category	SARS-CoV
Description	Methylprednisolone-d3 is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.

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Synonyms	U 7532-d3
Molecular Weight	377.49
Molecular Formula	C22H27D3O5
Canonical SMILES	C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([2H])[C@@]([C@H](C1([2H])[2H])O)([H])[C@@]4(C([C@H](C3)C)=CC(C=C4)=O)C
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	754
Exact Mass	377.22815429
In Vitro	Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Methylprednisolone is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used for vestibular neuritis. After six months the patients who were treated with methylprednisolone within eight hours of their injury had significant improvement as compared with those given placebo in motor function (neurologic change scores of 16.0 and 11.2, respectively; P = 0.03) and sensation to pinprick (change scores of 11.4 and 6.6; P = 0.02) and touch (change scores, 8.9 and 4.3; P = 0.03). Benefit from methylprednisolone was seen in patients whose injuries were initially evaluated as neurologically complete, as well as in those believed to have incomplete lesions.
Target	Glucocorticoid Receptor; Autophagy; SARS-CoV
XLogP3-AA	1.9