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Antiviral API
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Methyl gallate
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 99-24-1 |
| Description | Methyl gallate isolated from the herbs of Sapium sebiferum. It is a reverse transcriptase inhibitor. |
Product Information
| Synonyms | Methyl 3,4,5-trihydroxybenzoate; 3,4,5-trihydroxy-benzoicacimethylester |
| IUPAC Name | methyl 3,4,5-trihydroxybenzoate |
| Molecular Weight | 184.15 |
| Molecular Formula | C8H8O5 |
| Canonical SMILES | COC(=O)C1=CC(=C(C(=C1)O)O)O |
| InChI | InChI=1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3 |
| InChIKey | FBSFWRHWHYMIOG-UHFFFAOYSA-N |
| Boiling Point | 450.1±40.0 °C at 760 mmHg |
| Melting Point | 201-203 ℃ (lit.) |
| Flash Point | 190.8±20.8 °C |
| Purity | 0.98 |
| Density | 1.5±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Powder |
| Application | Used as an antioxidant. |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 181 |
| Exact Mass | 184.03717335 |
| Index Of Refraction | 1.631 |
| In Vitro | The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL). Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate. |
| PSA | 86.99000 |
| Target | Bacterial; HIV; Reactive Oxygen Species |
| Vapor Pressure | 0.0±1.1 mmHg at 25°C |
| XLogP3-AA | 0.9 |
