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Antiviral API
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Maslinic acid
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 4373-41-5 |
| Description | Maslinic acid is a pentacyclic triterpene found in a variety of natural sources. It exerts a wide range of biological activities, such as antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. |
Product Information
| Synonyms | Crategolic acid; 2α-Hydroxyoleanolic acid |
| Molecular Weight | 472.7 |
| Molecular Formula | C30H48O4 |
| Canonical SMILES | CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1)C)C(=O)O)C |
| InChI | InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1 |
| InChIKey | MDZKJHQSJHYOHJ-LLICELPBSA-N |
| Boiling Point | 570.0±50.0 °C at 760 mmHg |
| Melting Point | 267~269 °C |
| Flash Point | 312.6°C |
| Purity | >98% |
| Density | 1.14g/cm3 |
| Solubility | water, 0.00396 mg/L @ 25 °C (est) |
| Appearance | Powder |
| Application | antioxidant; anti-HIV; |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 919 |
| Exact Mass | 472.35526001 |
| Index Of Refraction | 1.568 |
| In Vitro | Maslinic acid (MA) inhibits LPS-induced NF-κB translocation to nucleus and phosphorylation of IκB-α. Maslinic acid has also been reported to suppress NF-κB regulated osteoclastogenesis in bone marrow monocytes and inhibit TNF-α-induced NF-κB activity and its downstream genes' expression in pancreatic cancer cells. To confirm if the anti-inflammatory effects of olive pomace extracts (OPEs) inRAW264.7 cells can be attributed to Maslinic acid, dose-dependence experiments determined the effective concentration of Maslinic acid to be 10-20 μM. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Pretreatment with Maslinic acid significantly reduces the LPS-induced phosphorylation of IκB-α. |
| In Vivo | Paw swelling is alleviated when mice are administered with 200 mg/kg Maslinic acid (MA), significantly suppressing inflammation, compared to the carrageenan induced control group, 4 h after λ-carrageenan injection (0.91±0.51 mm and 1.79±0.4 mm, respectively). |
| PSA | 77.76000 |
| Target | NF-κB; Bacterial; HIV |
| Vapor Pressure | 0.0±3.6 mmHg at 25°C |
| XLogP3-AA | 6.5 |
