α-Mangostin

Category	Virus Protease
CAS	6147-11-1
Description	It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent. It can inhibit the activity of COX-2, an inhibitor of mutant IDH1 (IDH1-R132H).

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Product Information

Synonyms	1,3,6-Trihydroxy-7-methoxy-2,8-bis(3,3-dimethylallyl)xanthone; α-Mangosten; NSC 139154; NSC 27593; NSC 30552
IUPAC Name	1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
Molecular Weight	410.46
Molecular Formula	C24H26O6
Canonical SMILES	CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
InChI	InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey	GNRIZKKCNOBBMO-UHFFFAOYSA-N
Boiling Point	640.1±55.0°C at 760 Torr
Melting Point	180-181°C
Flash Point	220.3±25.0 °C
Purity	>98%
Density	1.265±0.06 g/cm3
Solubility	Soluble in DMSO (37 mg/mL)
Appearance	Yellow Crystals
Storage	Store at 2-8°C
Animal Admin	Male Wistar rats are divided into 3 groups and treated with intraperitoneal injections of TAA (200 mg/kg). One subgroup is left untreated whereas the other two are treated either with 100 mg/kg alpha-mangostin or vehicle alone (80% DMSO, 20% water). The incidence offibrotic nodules on the liver and the serum levels of the liver enzymes aspartate transaminase (AST) and alanine transaminase (ALT) are measured.
Exact Mass	410.172943
Index Of Refraction	1.624
In Vitro	Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. It also significantly inhibits light-induced degeneration of photoreceptors and 200 μM H2O2-induced Apoptosis of RPE cells.
In Vivo	Alpha-mangostin reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
PSA	100.13000
Target	IC50: 2.85 μM (IDH1-R132H)
Vapor Pressure	0.0±2.0 mmHg at 25°C