Lysozyme from chicken egg white

Category	Human immunodeficiency Virus (HIV)
CAS	12650-88-3
Description	It's a bactericidal enzyme found in eggs that lyses gram-positive bacteria.

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Synonyms	12650-88-3;Lysozymum;LYSOZYME;Lysozyme, Egg White;AT25331;DA-75223;H-DL-Arg-DL-Val-DL-Val-DL-Arg-DL-Asp-DL-Pro-DL-Gln-Gly-DL-xiIle-DL-Arg-DL-Ala-DL-Trp-DL-Val-DL-Ala-DL-Trp-DL-Arg-DL-Asn-DL-Arg-OH;LYSOZYME FROM CHICKEN EGG WHITE(ENZYME ACTIVITY MIN 45000 FIP/MG);
IUPAC Name	2-[[4-amino-2-[[2-[[2-[2-[[2-[[2-[2-[[2-[[2-[[2-[[5-amino-2-[[1-[2-[[2-[[2-[[2-[(2-amino-5-carbamimidamidopentanoyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoylamino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoic acid
InChI	InChI=1S/C99H159N37O23/c1-11-50(8)77(132-72(139)46-120-81(145)63(32-33-70(101)137)124-88(152)69-31-21-39-136(69)93(157)68(43-73(140)141)131-84(148)62(29-19-37-116-98(109)110)125-90(154)75(48(4)5)135-91(155)76(49(6)7)133-80(144)57(100)24-16-34-113-95(103)104)92(156)126-60(27-17-35-114-96(105)106)82(146)121-51(9)78(142)129-66(41-54-45-119-59-26-15-13-23-56(54)59)87(151)134-74(47(2)3)89(153)122-52(10)79(143)128-65(40-53-44-118-58-25-14-12-22-55(53)58)85(149)123-61(28-18-36-115-97(107)108)83(147)130-67(42-71(102)138)86(150)127-64(94(158)159)30-20-38-117-99(111)112/h12-15,22-23,25-26,44-45,47-52,57,60-69,74-77,118-119H,11,16-21,24,27-43,46,100H2,1-10H3,(H2,101,137)(H2,102,138)(H,120,145)(H,121,146)(H,122,153)(H,123,149)(H,124,152)(H,125,154)(H,126,156)(H,127,150)(H,128,143)(H,129,142)(H,130,147)(H,131,148)(H,132,139)(H,133,144)(H,134,151)(H,135,155)(H,140,141)(H,158,159)(H4,103,104,113)(H4,105,106,114)(H4,107,108,115)(H4,109,110,116)(H4,111,112,117)
InChIKey	ZJCXKXFAOCLSRV-UHFFFAOYSA-N
Solubility	Soluble in Water
Appearance	Solid
Application	Lysozyme is a naturally occurring enzyme found in large quantities in chicken egg white that has shown great potential in the field of drug development. This versatile enzyme has attracted much attention for its antimicrobial properties and its ability to catalyze the hydrolysis of peptidoglycan, a key component of the bacterial cell wall. Antimicrobial Properties: Strong antibacterial activity is one of lysozyme's most well-known characteristics. Lysozyme is an efficient way to stop the growth of a variety of bacteria, both gram-positive and gram-negative, by specifically targeting and dissolving the peptidoglycan layer of the bacterial cell wall. Because of its antimicrobial properties, lysozyme is an invaluable resource for the creation of novel antimicrobial drugs and tactics to treat bacterial infections, particularly in light of the rise in antibiotic resistance. Lysozyme has been investigated by researchers as a potential natural substitute for conventional antibiotics, either on its own or in conjunction with other antimicrobial agents. Research has demonstrated that the use of lysozyme in conjunction with antibiotics has a synergistic impact that enables the use of lower antibiotic dosages while still producing efficient bacterial suppression. This not only helps reduce the risk of antibiotic resistance, but also minimizes potential side effects associated with high doses of antibiotics. Immunomodulatory Effects: Lysozyme has been shown to possess immunomodulatory qualities in addition to antibacterial ones, which may aid in controlling immunological responses. Research have demonstrated that lysozyme affects cytokine synthesis and antigen presentation, which in turn affects the activity of immune cells, including dendritic cells and macrophages. Lysozyme's immunomodulatory action is promising for the creation of vaccinations and immunotherapies. Researchers are investigating lysozyme's potential uses in cancer immunotherapy, allergies, and autoimmune illnesses by taking use of its immunomodulatory properties. Vaccines based on lysozymes, for instance, have demonstrated potential in boosting the immune system's ability to identify and target cancer cells, therefore boosting anti-tumor immune responses. In addition, the ability of lysozyme to modulate immune cell function could provide new insights into the treatment of autoimmune diseases by modulating aberrant immune responses. Drug Delivery Systems: The creation of novel drug delivery methods is another field of drug discovery that has made use of egg white lysozyme. Through the utilization of lysozyme's enzyme activity, scientists have developed drug carriers that are capable of precisely targeting infection or inflammatory areas. By using lysozyme's ability to cleave peptidoglycan, these drug delivery methods allow for precise and localized drug release. Drug delivery methods based on lysozymes have demonstrated potential to increase drug delivery's specificity and efficacy, especially when treating bacterial infections and inflammation. Researchers can improve the targeting and uptake of therapeutic substances by bacterial cells or immune cells at the site of infection by mixing medications or nanoparticles with lysozyme. This targeted delivery approach can not only enhance the therapeutic effect of drugs, but also reduce systemic side effects, making it a promising strategy for developing precision medicine. Wound healing applications: In addition to its antimicrobial and immunomodulatory properties, lysozyme has been studied for its potential to promote wound healing. Studies have shown that lysozyme can accelerate the wound healing process by promoting cell proliferation, migration, and tissue regeneration. By stimulating the production of growth factors and extracellular matrix proteins, lysozyme plays a vital role in tissue repair and regeneration. The wound healing properties of lysozyme have prompted the exploration of developing advanced wound dressings and topical preparations for the treatment of acute and chronic wounds. By incorporating lysozyme into wound care products, researchers aim to enhance the healing process, reduce the risk of infection, and improve overall patient outcomes. In addition, the ability of lysozyme to modulate immune responses in the wound microenvironment could provide new therapeutic strategies for treating complex wounds and promoting tissue regeneration.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.