-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
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- Endogenous Metabolite
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- Antiviral intermediates
Loviride
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 147362-57-0 |
| Description | Loviride is an RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. |
Product Information
| Synonyms | R 89439; R-89439; alpha-APA; (+-)-2-(6-Acetyl-m-toluidino)-2-(2,6-dichlorophenyl)acetamide |
| IUPAC Name | 2-(2-acetyl-5-methylanilino)-2-(2,6-dichlorophenyl)acetamide |
| Molecular Weight | 351.23 |
| Molecular Formula | C17H16Cl2N2O2 |
| Canonical SMILES | CC1=CC(=C(C=C1)C(=O)C)NC(C2=C(C=CC=C2Cl)Cl)C(=O)N |
| InChI | InChI=1S/C17H16Cl2N2O2/c1-9-6-7-11(10(2)22)14(8-9)21-16(17(20)23)15-12(18)4-3-5-13(15)19/h3-8,16,21H,1-2H3,(H2,20,23) |
| InChIKey | CJPLEFFCVDQQFZ-UHFFFAOYSA-N |
| Boiling Point | 550.3±50.0 °C at 760 mmHg |
| Melting Point | 226.3°C |
| Flash Point | 286.6°C |
| Purity | 99% |
| Density | 1.44 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Light yellow to yellow (Solid) |
| Storage | Store at -20°C |
| Complexity | 436 |
| Exact Mass | 350.0588831 |
| Index Of Refraction | 1.637 |
| In Vitro | Loviride (0.01 µM) inhibits HIV-1(IIIB) replication in MT-4 cells, also inhibits HIV-2 and SIV, with EC50s of 85.5, 7.4 µM for HIV-2 (ROD), HIV-2 (EHO), and 11.4, 28.5, 57.0 µM for SIV (mac251), SIV (agm3), SIV (mndGB1), respectively. |
| PSA | 73.18000 |
| Target | Reverse Transcriptase; HIV |
| Vapor Pressure | 3.69E-12mmHg at 25°C |
| XLogP3-AA | 4.4 |
