Lopinavir-d8

Category	HIV Protease
CAS	1224729-35-4
Description	Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.

Quotation Now

Synonyms	Lopinavir-d8\|1322625-54-6\|2,3,4,4,4-pentadeuterio-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-2-(2-oxo-1,3-diazinan-1-yl)-3-(trideuteriomethyl)butanamide
Molecular Weight	636.85
Molecular Formula	C37H48N4O5
Canonical SMILES	CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O
Boiling Point	924.2±65.0 °C at 760 mmHg
Flash Point	512.7±34.3 °C
Purity	≥98% (HPLC)
Density	1.2±0.1 g/cm3
Solubility	Chloroform: Slightly Soluble,Methanol: Slightly Soluble
Appearance	Solid powder
Storage	Store at -20°C
Complexity	940
Exact Mass	636.41268461
Index Of Refraction	1.577
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
Target	HIV; HIV Protease; SARS-CoV
Vapor Pressure	0.0±0.3 mmHg at 25°C
XLogP3-AA	5.9