Required fields are marked with *

Lopinavir-[d8]

{PARAM:[Name]}({[CAS]})
Category HIV Protease
CAS 1224729-35-4
Description Lopinavir-[d8] is the labelled form of Lopinavir, which is a selective HIV protease inhibitor used as an antiretroviral medication.
Quotation Now

Product Information

Synonyms Lopinavir D8; ABT 378-d8; Aluviran-d8; Koletra-d8; (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-[1-(methyl-d3)ethyl-1,2,2,2-d4]-2-oxo-1(2H)-pyrimidineacetamide-α-d
IUPAC Name (2S)-2,3,4,4,4-pentadeuterio-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-2-(2-oxo-1,3-diazinan-1-yl)-3-(trideuteriomethyl)butanamide
Molecular Weight 636.85
Molecular Formula C37H40D8N4O5
Canonical SMILES [2H][C@@](C(=O)N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(=O)COC3=C(C=CC=C3C)C)O)(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])N4CCCNC4=O
InChI InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1/i1D3,2D3,25D,34D
InChIKey KJHKTHWMRKYKJE-FQJAQOFRSA-N
Boiling Point 924.2±65.0 °C at 760 mmHg
Flash Point 512.7±34.3 °C
Purity 98% by CP; 98% atom D
Density 1.2±0.1 g/cm3
Solubility Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance Off-white to pale beige solid
Storage Store at 2-8 °C
Complexity 940
Exact Mass 636.41268461
Index Of Refraction 1.577
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
Target HIV; HIV Protease; SARS-CoV
Vapor Pressure 0.0±0.3 mmHg at 25°C
XLogP3-AA 5.9

TAKE YOUR NEXT STEPS

Get Started With Our Industry Experience And Client-Centric Focus!

Talk to Us

Copyright © 2025 BOC Sciences. All rights reserved.