Lipid ALC-0315

Category	SARS-CoV
CAS	2036272-55-4
Description	ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system).

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Synonyms	ALC-0315; ((4-Hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate)
IUPAC Name	6-[6-(2-hexyldecanoyloxy)hexyl-(4-hydroxybutyl)amino]hexyl 2-hexyldecanoate
Molecular Weight	766.27
Molecular Formula	C48H95NO5
Canonical SMILES	CCCCCCCCC(CCCCCC)C(=O)OCCCCCCN(CCCCCCOC(=O)C(CCCCCC)CCCCCCCC)CCCCO
InChI	InChI=1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3
InChIKey	QGWBEETXHOVFQS-UHFFFAOYSA-N
Boiling Point	760.6±55.0 °C at 760 mmHg
Flash Point	413.8±31.5 °C
Purity	>98%
Density	0.9±0.1 g/cm3
Solubility	In Vitro: DMSO : 50 mg/mL(65.25 mM;Need ultrasonic) Ethanol : 100 mg/mL(130.50 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution
Appearance	Colorless to Yellowish Oily Liquid
Storage	Store at -20°C
Complexity	718
Exact Mass	765.721008
Index Of Refraction	1.472
In Vitro	ALC-0315 is used to form lipid nanoparticle for the research of vaccination.
In Vivo	ALC-0315 is used to form lipid nanoparticle for the research of vaccination.
Target	SARS-CoV
Vapor Pressure	0.0±5.8 mmHg at 25°C
XLogP3-AA	17.3