Levofloxacin hydrate

Category	Orthopoxvirus
CAS	138199-71-0
Description	The hydrate form of Levofloxacin, an Ofloxacin derivative, could be commonly used as an antibacterial agent through influencing DNA replication. It is an antibiotic with activity against gram-negative bacteria.

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Synonyms	Levofloxacin Hemihydrate;138199-71-0;Levofloxacin hydrate;Nofaxin;Volequin;Levofloxacin (hydrate);Dynaquin;Ofloxacin, (s)-;6GNT3Y5LMF;Levofloxacin (as hemihydrate);UNII-6GNT3Y5LMF;RWJ-25213;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrate(2:1);Levaquin (TN);(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, hemihydrate;7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-hydrate (2:1), (S)-;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-;Levofloxacin [USAN];LEVOFLOXACIN [MART.];LEVOFLOXACIN [USP-RS];DTXSID60160533;RWJ 25213;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hemihydrate;Ofloxacin s-(-)-form hemihydrate;LEVOFLOXACIN [USP MONOGRAPH];LEVOFLOXACIN HEMIHYDRATE [EP MONOGRAPH];MFCD07772024;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (3S)-; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (S)-; Dynaquin; Leeflox; Levofloxacin; Levofloxacin hydrate;Levofloxacin (USP);Quixin (TN);Iquix (TN);LevofloxacinHemihydrate;LEVOFLOXACIN [VANDF];(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hydrate (2:1);Levofloxacin hydrate (JP18);LEVOFLOXACIN HEMIHIDRATED;SCHEMBL1650602;CHEMBL5315124;LEVOFLOXACIN [ORANGE BOOK];LEVOFLOXACIN HYDRATE [JAN];AKOS015896149;KS-1077;Levofloxacin [USAN:USP:INN:BAN:JAN];LEVOFLOXACIN HEMIHYDRATE [WHO-DD];7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, hydrate (2:1), (S)-;DA-54880;D00588;OFLOXACIN S-(-)-FORM HEMIHYDRATE [MI];A886273;EN300-20644132;Q47495791;Levofloxacin, United States Pharmacopeia (USP) Reference Standard;Levofloxacin Hemihydrate, Pharmaceutical Secondary Standard; Certified Reference Material;(S)-(-)-Ofloxacine; Levofloxacine; (-)-(s)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride; Levofloxacin hemihydrate;(S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid Hemihydrate;(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid hemihydrate;bis((2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0,5,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid) hydrate;
IUPAC Name	(2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrate
Molecular Weight	370.38
Molecular Formula	C18H21FN3O4.5
Canonical SMILES	O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C23)O.[0.5H2O]
InChI	InChI=1S/2C18H20FN3O4.H2O/c21-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h27-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1
InChIKey	SUIQUYDRLGGZOL-RCWTXCDDSA-N
Boiling Point	571.5°C at 760 mmHg
Melting Point	218-227°C
Purity	98%
Density	1.48 g/cm3
Solubility	Slightly soluble in Basic Aqueous Solution, DMSO, Methanol
Appearance	Solid
Application	Anti-Bacterial Agents
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)