Levamisole hydrochloride

Category	Herpes simplex Virus (HSV)
CAS	16595-80-5
Description	Levamisole hydrochloride, the hydrochloride salt of a water-soluble imidazothiazole derivative, selectively activates acetylcholine receptor ion channels in nerve and muscle of nematodes (EC50 = 6 µM). It has anthelminthic and immunomodulating activities.

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Product Information

Synonyms	Levamisole HCl; Ergamisol; (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride
IUPAC Name	(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
Molecular Weight	240.75
Molecular Formula	C11H13ClN2S
Canonical SMILES	C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
InChI	InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
InChIKey	LAZPBGZRMVRFKY-HNCPQSOCSA-N
Boiling Point	344.4°C at 760 mmHg
Melting Point	227-229 °C
Flash Point	162.1°C
Purity	98%
Solubility	DMSO: ≥ 15.5 mg/mL
Appearance	White to Off-white Crystalline Powder
Application	APIs for Veterinary
Shelf Life	2 years
Storage	Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -62°C for long term (months to years).
Complexity	246
Exact Mass	240.0487973
In Vitro	Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging.
PSA	40.90000
Target	Parasite; HSV