Leptomycin A

Category	Human immunodeficiency Virus (HIV)
CAS	87081-36-5
Description	a potent anti-fungal antibiotic. Leptomycin A is a highly specific inhibitor of export protein CRM1.

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Product Information

Synonyms	Leptomycin A;Jildamycin;87081-36-5;(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid;NSC 369326;NSC369326;ATS1287 A, LMA;SCHEMBL14190847;MFCD01711669;BS-1083;NSC-369326;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-;2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-;DA-54856;NS00011727;Leptomycin A; Antibiotic ATS 1287A; Antibiotic PD 118607; Jildamycin;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-Hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid;2,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-;
IUPAC Name	(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Molecular Weight	266.32
Molecular Formula	C12H14N2O3S
Canonical SMILES	CC(=O)SC1=CC=CC=C1C(=O)NCCC(=O)N
InChI	InChI=1S/C32H46O6/c1-20(16-22(3)12-14-28-24(5)13-15-30(35)38-28)10-9-11-21(2)17-25(6)31(36)27(8)32(37)26(7)18-23(4)19-29(33)34/h9,11-17,19-20,24-28,32,37H,10,18H2,1-8H3,(H,33,34)/b11-9+,14-12+,21-17+,22-16+,23-19+
InChIKey	QECBVZBMGUAZDL-DLWOFZAMSA-N
Boiling Point	717.7°C at 760 mmHg
Purity	>99% by HPLC
Density	1.079 g/cm3
Solubility	Soluble in ethanol or methanol poor water solubility ethanol recommended unstable in DMSO
Appearance	Solid
Storage	-20 °C