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Leptomycin-A
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 7081-36-5 |
| Description | Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B. |
Product Information
| Synonyms | Leptomycin A|Jildamycin|87081-36-5|(2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid|NSC 369326|NSC369326|Antibiotic PD-118607|SCHEMBL14190847|BS-1083|NSC-369326|2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-|2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-|Leptomycin A, from Streptomyces sp., ~95% (HPLC), methanol solution|Leptomycin A; Antibiotic ATS 1287A; Antibiotic PD 118607; Jildamycin|(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-Hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid|102490-63-1|2,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo- |
| Molecular Weight | 526.7 |
| Molecular Formula | C32H46O6 |
| Canonical SMILES | CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C |
| Boiling Point | 717.7ºC at 760 mmHg |
| Flash Point | 224.2ºC |
| Purity | ≥98% (HPLC) |
| Density | 1.079g/cm3 |
| Solubility | Ethanol: Soluble, Methanol: Soluble |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 1010 |
| Exact Mass | 526.32943918 |
| Index Of Refraction | 1.544 |
| PSA | 100.90000 |
| Target | CRM1; HIV |
| XLogP3-AA | 7.4 |
