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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
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- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
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- Rabies virus (RABV)
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- SARS-CoV
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- West Nile virus
- Antiviral intermediates
Laninamivir
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| Category | Influenza Virus |
| CAS | 203120-17-6 |
| Description | Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively. |
Product Information
| Synonyms | 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid; R 125489; (4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid |
| IUPAC Name | (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-2,3-dihydroxy-1-methoxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid |
| Molecular Weight | 346.34 |
| Molecular Formula | C13H22N4O7 |
| Canonical SMILES | CC(=O)NC1C(C=C(OC1C(C(CO)O)OC)C(=O)O)N=C(N)N |
| InChI | InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1 |
| InChIKey | QNRRHYPPQFELSF-CNYIRLTGSA-N |
| Purity | 99.91% |
| Density | 1.4±0.1 g/cm3 |
| Solubility | In Vitro: H2O : 5 mg/mL(14.44 mM;Need ultrasonic) |
| Appearance | White to off-white (Solid) |
| Application | Antiviral Agents |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 532 |
| Exact Mass | 346.14884905 |
| Index Of Refraction | 1.572 |
| In Vitro | Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution. Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir. |
| Target | Influenza Virus |
| XLogP3-AA | -3.2 |
