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KIN1408

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Category Hepatitis C Virus (HCV)
CAS 1903800-11-2
Description KIN1408 is an IRF3 activator with antiviral activity. It induces innate immune gene expression such as MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA).
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Product Information

Synonyms 7-[[4-(Difluoromethoxy)phenyl]-[(5-methoxy-1,3-benzothiazol-2-yl)amino]methyl]quinolin-8-ol
Molecular Weight 479.5
Molecular Formula C25H19F2N3O3S
Canonical SMILES COC1=CC2=C(C=C1)SC(=N2)NC(C3=CC=C(C=C3)OC(F)F)C4=C(C5=C(C=CC=N5)C=C4)O
InChI InChI=1S/C25H19F2N3O3S/c1-32-17-9-11-20-19(13-17)29-25(34-20)30-21(15-4-7-16(8-5-15)33-24(26)27)18-10-6-14-3-2-12-28-22(14)23(18)31/h2-13,21,24,31H,1H3,(H,29,30)
InChIKey YSGBFDHVEQJPPX-UHFFFAOYSA-N
Purity ≥98%
Solubility In Vitro:
DMSO : ≥ 39 mg/mL(81.33 mM)
Appearance Solid Powder
Storage Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
Complexity 657
Exact Mass 479.11151897
In Vitro KIN1408 has the potency to drive IRF3 activation to induce innate immune gene (MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells) expression and that concomitantly suppress dengue virus2 RNA to levels. KIN1408 also exhibits activity against HCV, influenza A, Ebola, Nipah, and Lassa viruses.
Target HCV; Influenza Virus
XLogP3-AA 6.7

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